Zinc, energy levels and mood - best destressing method

Taking zinc decreases anxiety especially taking it after few days of inhibitory supplements such as Thiamine.

Last few days, I have been taking thiamine HCl 25 mg two times daily. Today, I did not take thiamine. Instead, I took zinc gluconate (equivalent to 25 mg elemental zinc). I could feel good mood, less anxiety, good working memory and less post lunch sleepiness.

Daily aerobic exercise coupled with zinc for few days appears to destress and elevate mood.

Effect of Wellman multivitamins

 I have taken Wellman multivitamins for last 25 days. It contains general multivitamins in low concentration and Siberian Ginseng extract 20 mg.

Positive effects:

1. Anxiety is very much reduced. No fear / hesitation to go to office

2. Stuttering was manageable in the starting --> gradually worsened a little bit.

Negative effects:

1. Focus and concentration is very much reduced. Unable to concentrate on research and write research papers.

2. Unable to remember the counts of parts of prayer while praying

3. Unable to handle many things at the same time --> led to postponement of many works.

Food items and their impact on neurotransmitters

Whenever I consume the following foods items, I experience the following feelings.

1. Refined sugar - increased stuttering
2. Brown sugar/Jaggery - slightly increased stuttering
3. Full cream milk powder - reduced anxiety
4. Roasted ground nut with/without skin - Reduced anxiety/slightly increased energy/Slightly reduced stuttering
5. Roasted green peas - Increased stuttering
6. Butter consumption at dinner - slightly increased energy next morning, reduced stuttering next day
7. No sugar consumption - wrinkles on nails, dry skin, easy bruisability of skin, increased vocal blocks, reduced loudness of voice, good initiation to start a work, good concentration and focus to remain in a task

Less Anxiety and Less Stuttering

I have been fasting these days. Two weeks before fasting, I started taking two boiled eggs every day at dinner in order to increase testosterone levels. Also, I have been taking thiamine mononitrate 50 mg per day (25 mg in morning and 25 mg in night). I was taking multivitamin B complex tablets (Multi B, Blackmores) also. Later I changed to supradyn recharge. I took supradyn recharge on alternate days. I added 3.325 mg of methylfolate in the night to increase focus and concentration.

During the fasting, I avoided rice completely and used to take parotta or chappathi. I avoided coffee or tea completely. I took only black lemon tea and later switched to green tea with little sugar (no milk). Also, I changed from Dove soap to Chandrika soap for bath.

These combination of diet, supplements and lifestyle modification produced a dramatic effect. No anxiety before talking. Less stuttering and no gasping for breath during talking. It seems that my multiple chemical sensitivity is reduced much.

Possible mechanism:

The combination of these supplements might have reduced inflammation in the body. The inflammation weakens the blood brain barrier. Due to high permeability of blood brain barrier, many chemicals might have entered into the brain, thus disturbing neurotransmitters systems. The disturbed neurotransmitter systems might have caused mood changes and increased stuttering etc.

Effect of folic acid, methyl folate, zinc and vitamin B6

During the course of several multivitamin tablets and capsules, I observed the effects of few components such as folic acid, methylfolate, zinc and vitamin B6. Actually, these effects are observed when these compounds are taken along with a multivitamin tablet/capsule. Those multivitamin tablet/capsule contain less than daily recommended value of folic acid, zinc and vitamin B6.

When taken alone, zinc 15 mg gives sleepiness and dullness. In contrast, when zinc and vitamin B6 (at least 6 mg) are combined, it gives opposite effect. With this combination, sometimes I don't feel sleepy even around 1.30 am. But If I lie down on bed, I used to get good sleep and complete sleep. Even if it is a 6 hrs sleep, after getting up, even though I still feel the same tiredness and inertia, I don't get the feeling of "not slept enough". Earlier, I used to get "not slept enough....need to sleep for long hours to make up the loss" feeling, if i sleep less than 8 or 9 hours. Because of this feeling, I used to sleep for 8-10 hours during the weekends and 7-9 hours during the weekdays. with zinc and B6 combination, I never worried about sleep debt. Some afternoons, I felt sleepy. But, no urge to lie down and sleep. Earlier, many times I used to go to house and sleep from office. Those times, simply I could not control my sleepiness.

Zinc, when taken alone or in combination gives good muscle flexibility and endurance to sustain 45 minutes of pedaling in cross trainer. However, zinc taken at night disturbs the sleep and the next day I used to feel sleepy. Zinc also heals the skin bruises and scratches fast. My skin around the hand finger nails used to peel off after getting scratched while inserting into my back pant pocket. After taking zinc, simply I don't get this. 

Compound	Effect	Remarks
Folic acid	2.5 mg of folic acid gives energy and feelings of pleasure. When listening to music, it gives a very good feeling of intense happiness (just one level below mild euphoria )
Methylfolate	3.75 mg of methylfolate gives mainly enhancement of serotonergic function leading to dullness and sleepiness. On prolonged administration more than 2 weeks, it gives stabilized mood and energy.
Zinc	15 mg of zinc + vitamin C 250 mg Positive effects ·         good energy and positive mood, ·         reduced day time sleepiness (not completely abolishing but to some extent), ·         feeling of completed sleep ·         Healing of skin scratches and bruises ·         No gasping for breath while exercising, while climbing stairs and while talking Negative effects profuse sweating, pronounced stuttering, reduced fluency, non-stutterable pause, slightly reduced motivation, significantly reduced concentration and focus, reduced libido and erections. 7.5 mg – 10 mg of zinc in the form of aminochelate All the above effects in reduced intensity (dose-dependent reduction) with improved speech fluency and reduced stuttering but still mild non-stutterable pause is there	Without the zinc, I used to feel sleepy and lethargic with any multivitamin combination. After I observed non-stutterable pause, I stopped taking zinc. The next day, great improvement in energy, mood and almost nil non-stutterable pause was observed. I googled and found that Zinc can induce Parkinson's like syndrome in animal models by causing death of striatal dopaminergic neurons. Minocycline Rescues from Zinc-Induced Nigrostriatal Dopaminergic Neurodegeneration: Biochemical and Molecular Interventions.
Vitamin B6 / Pyridoxine HCl	1-5 mg gives moderate energy, focus and concentration. 5-10 mg gives optimum energy, focus and concentration. Above 10 mg gives profuse sweating, sleepiness, reduced loudness of speech and little anxiety due to pronounced stuttering

Effects of Methylfolate in combination with other nutrients

I took methylfolate along with other nutrients for fine tuning the benefits of methylfolate.

	L-methylfolate 7.5 mg/day (3.25 mg in morning and 3.25 mg in night) + Pyridoxine HCl 10 mg/day (5 mg in morning and 5 mg in night) + methylcobalamin 500 microgram/day (500 microgram in morning)	L-methylfolate 7.5 mg/day (3.25 mg in morning and 3.25 mg in night) + one capsule of Supradyn recharge in morning + methylcobalamin 500 microgram/day (500 microgram in morning) + Pyridoxine HCl 5 mg in night	L-methylfolate 7.5 mg/day (3.25 mg in morning and 3.25 mg in night) + one capsule of Supradyn recharge in morning + methylcobalamin 500 microgram/day (250 microgram in morning and 250 microgram in night)	L-methylfolate 7.5 mg/day (3.25 mg in morning and 3.25 mg in night) + one tablet of zincovit in morning + methylcobalamin 500 microgram/day (250 microgram in morning and 250 microgram in night) + one tablet of Calcium & Magnesium Plus (Elemental calcium 275.9 mg + elemental magnesium 125 mg + elemenatl manganese 1.5 mg + elemental zinc 300 microgram + Vitamin D3 100 IU)
Effects on anxiety	No anxiety	No anxiety	No anxiety	No anxiety
Effects on depression	No depressive feelings	No depressive feelings	No depressive feelings	No depressive feelings
Effects on stuttering and voice	Mild stuttering. Can make a fluent conversatioatin. No effect on loudness of voice	Less stuttering. Can make a fluent conversation. Good loudness of voice	Less stuttering. Can make a fluent conversation. Good loudness of voice	Less stuttering. Can make a somewhat fluent conversation. moderate loudness of voice
Effects on motivation	Slightly reduced Motivation	Reduced Motivation	Average motivation;. If methylcobalamin dose in increased, it produces less motivation and lethargic effects similar to that of fluoxetine. If methylfolate dose is increased, it creates increased motivation and restlessness.	Average motivation
Effects on concentration	Slightly reduced concentration throughout the day	Reduced concentration throughout the day	Slightly reduced concentration throughout the day	Average concentration
Effects on memory	Good	Good	Good
Effects on mental fog and clarity of thinking	Slightly reduced clarity of thinking	Reduced clarity of thinking	Nil to Slightly reduced clarity of thinking
Effects on telephonic conversation	Mild stuttering	Mild stuttering	Less stuttering and good speech
Effects on affection and social life	Neutral	Reduced affection towards family	Neutral
Effects on sleep	Not excessive sleepiness. Able to get up early in morning	Excessive sleepiness. Not able to get up early in morning, Uncontrollable sleeping after lunch in evening	Neutral
Effects on libido and sex	Neutral	Neutral	Neutral	seems to increase libido...gives good spontaneous erections...able to get strong erection after massaging for masturbation (this effect was better observed with medimix soap/chandrika soap). The soap is used for bathing only and not during the time of masturbation.
Effects on eye vision	Neutral	Neutral	Neutral
Effects on driving	Neutral	Neutral	Neutral
Effects on body temperature and sweating	Slightly increased sweating	Slightly increased sweating	Reduced body temperature and sweating
Other effects	Slight bad taste in mouth, mild skins rashes like an allergic reaction (red skin eruptions appear in line)	Slight bad taste in mouth, mild skins rashes like an allergic reaction (red skin eruptions appear in line)	No bad taste in mouth. No skin allergies. (If the tablets are taken after food)
Diet during these time	Oats porridge in morning and night; lunch – rice with 200 g of chicken or fish with 200 g vegetables	Oats porridge in morning and night; lunch – rice with 200 g of chicken or fish with 200 g vegetables	Oats porridge in morning and night; lunch – rice with 200 g of chicken or fish with 200 g vegetables