Calcium supplementation increases dopamine

I have taken 1 tablet of neurobion forte multivitamin tablet + 1 tablet folic acid 1 mg daily for 10 days either in the morning after breakfast or after lunch.

Composition of Neurobion Forte Tablet:

Thiamine Hydrochloride (Vit B1) 10 MG

Riboflavin (Vit B2) 10 MG

Pyridoxine Hydrochloride(Vit B6) 3 MG

Cyanocobalamin triturate in gelatin equivalent to cyanocobalamin 15 MCG

Niacinamide (Nicotinamide/Vit B3) 45 MG

Calcium Pantothenate 50 mg

Also, I have taken Calmagic HD tablet for last 5 days along with the above tablets.

Composition of Calmagic HD tablet:

Elemental calcium 500 MG

Elemental magnesium 100 MG

Vitamin D3 1000 IU

I observed the following effects:

1. Decreased tension, decreased anxiety

2. Decreased heart rate (from ~ 90bpm to ~ 82 bpm) and decreased blood pressure (from ~128/86 mmHg ~ 116/78 mmHg)

3. Increased libido and increased erection

4. Slightly increased working memory

5. Increased ability to drive car at faster speeds with better steering control

6. Slightly increased stuttering

All these effects indicate that there is an increased dopaminergic activity. Similar effects were observed during the period 2014-2015 where I took calmagzinc + methylfolate + methylcobalamin.

Effect of Wellman multivitamins

 I have taken Wellman multivitamins for last 25 days. It contains general multivitamins in low concentration and Siberian Ginseng extract 20 mg.

Positive effects:

1. Anxiety is very much reduced. No fear / hesitation to go to office

2. Stuttering was manageable in the starting --> gradually worsened a little bit.

Negative effects:

1. Focus and concentration is very much reduced. Unable to concentrate on research and write research papers.

2. Unable to remember the counts of parts of prayer while praying

3. Unable to handle many things at the same time --> led to postponement of many works.

Effects of methylfolate

I took 5 mg of folic acid per day (2.5 mg in morning and 2.5 in night). I felt more energetic and motivated. So, I have started experimenting with methylfolate.

	L-methylfolate 7.5 mg/day (3.25 mg in morning and 3.25 mg in night) + one zincovit tablet  in morning + one Magcalzinc tablet in night (Elemental calcium 250 mg + Elemental magnesium 125 mg + elemental zinc 3 mg)	L-methylfolate 7.5 mg/day (3.25 mg in morning and 3.25 mg in night) + one zincovit tablet  in morning	L-methylfolate 7.5 mg/day (3.25 mg in morning and 3.25 mg in night)	L-methylfolate 7.5 mg/day (3.25 mg in morning and 3.25 mg in night) + one capsule of fluoxetine in night
Effects on anxiety	No anxiety	No anxiety	No anxiety	No anxiety
Effects on depression	No depressive feelings	No depressive feelings	No depressive feelings	No depressive feelings
Effects on stuttering and voice	Moderate stuttering was there. Cannot make a fluent conversation. Reduced loudness of voice	Moderate stuttering was there. Cannot make a fluent conversation. Reduced loudness of voice	Moderate to severe stuttering was there. Cannot make a fluent conversation or presentation. Reduced loudness of voice	Much reduced stuttering. Can make a good presentation and conversation. Good loudness of voice
Effects on motivation	Good motivation	Good motivation	Good motivation	Reduced motivation and increased lethargy
Effects on concentration	Good concentration throughout the day	Good concentration throughout the day	Good concentration on tasks in morning. Low concentration in afternoons. Then, concentration increases after 7 pm.	Reduced concentration
Effects on memory	Good	Good	Good	Good
Effects on mental fog and clarity of thinking	Good	Good	Good	Reduced clarity of thinking
Effects on telephonic conversation	Moderate stuttering	Moderate stuttering	Moderate stuttering	Reduced stuttering
Effects on affection and social life	Longing for love from family members but no interest in social life	Longing for love from family members but no interest in social life	Longing for love from family members but no interest in social life	Reduced affection towards family but increased participation in social gatherings probably due to less stuttering
Effects on sleep	No excessive sleepiness. Able to get up early in morning	No excessive sleepiness. Able to get up early in morning	Not much of excessive sleepiness. But, heavy uncontrollable sleepy feeling after taking lunch.	Increased sleepiness. Cannot get up easily in morning.
Effects on libido and sex	Neutral	Neutral	Neutral	Neutral to less
Effects on eye vision	Neutral	Neutral	Neutral	Neutral
Effects on driving	Neutral	Neutral	Neutral	Neutral
Effects on body temperature and sweating	No ‘heated body’ feeling and no increased sweating	No ‘heated body’ feeling and no increased sweating	No ‘heated body’ feeling and no increased sweating	Increased sweating
Other effects	Moderate right hand wrist pain and forearm pain was there due to excessive computer mouse usage, bad taste in mouth, mild skins rashes like an allergic reaction (red skin eruptions appear in line)	Mild right hand wrist pain and forearm pain was there due to excessive computer mouse usage, bad taste in mouth, mild skins rashes like an allergic reaction (red skin eruptions appear in line)	No hand pain or wrist pain, bad taste in mouth, bad breath, mild skins rashes like an allergic reaction (red skin eruptions appear in line)	Slight bad breath, mild skins rashes like an allergic reaction (red skin eruptions appear in line)
Diet during these time	Oats porridge in morning and night; lunch – rice with 200 g of chicken or fish with 200 g vegetables	Oats porridge in morning and night; lunch – rice with 200 g of chicken or fish with 200 g vegetables	Oats porridge in morning and night; lunch – rice with 200 g of chicken or fish with 200 g vegetables	Oats porridge in morning and night; lunch – rice with 200 g of chicken or fish with 200 g vegetables

Link between working memory, stress, anxiety, depression and stuttering

Working memory in human beings can be analogous to the computer RAM. More the RAM a computer has, faster the computer is. Having more RAM in a computer can help the computer to perform faster operations and multitasking. Similarly, availability of more working memory in humans will enable to do better multitasking at faster speeds.

For the past 4 days I am taking Ginkgo biloba 2500 mg extract. Also, I am walking 30 minutes everyday evening around 8 - 9 pm.

Composition:
Each capsule contains 50 mg of standardized extract (equivalent to 2500 mg of dry Ginkgo biloba leaves); contains 24% ginkgoflavonglycosides and 6% terpene lactones.

Positive effects:

• Good mood - really good mood with inflow of innate happiness
• Very less anxiety - anxiety was extremely less while speaking
• Almost no stuttering - very good fluency with more talkative nature; No anxiety while calling through phone.
• Increased libido - With good inflow of happiness, I am in a mood to look forward for sex. However, not strong erections.
• No headaches - really no headaches and my head is really very clear
• Able to get ready faster in the morning - around 1 hour to 1 hour 15 minutes. Before, it used to be 1 hour 30 minutes.
• My car driving speed increased tremendously. I am able to drive at 110-120km/h speed and at the same time enjoying music. (Earlier, whenever I accelerate to 110-120km/h speed, all my attention used to focus on driving and on the road. And also, I used to feel my adrenaline rush. Whenever car used to shake due to road imperfections, my adrenaline increased and all my attention focused on road and steering wheel). But, now, I am least bothered about the car shake and able to enjoy music. 2 days back, I was driving in the fast lane at 110-120km/h speed. I made 3 cars to change to slower lane to give me way, which were going in front of me. Such a tremendous speed of information processing never happened to me before while driving.
• Music is enjoyable very much.
• I have started watching movies also. Earlier, I lose patience in watching movies continuously.
• Able to make phone calls to relative without much stuttering and anxiety. This was not at all possible before. Earlier, I used to have fear of stuttering and anxiety of talking over phone. Due to this, I avoided calling my relatives which led to some misunderstanding amongst my relatives.  

Negative effects:

• More sleepy - sleeping time increased to 8-10 hours.
• Not very strong erections. But sustained increase in libido is observed. This libido seems to be linked with dopamine levels. Actually before taking this Ginkgo biloba, I was taking bupropion SR 150 mg for four days. Then I stopped it for 1 day. Then, the next day, I took this Gingko biloba. So, the residual bupropion remained in the body would have caused this increased libido possibly.

Neutral effects:

• Not significant increase in speed of working - but slightly increased motivation to remain in a task is observed. Still inertia to initiate the planned work is there.

Update on 27 June 2012:

• Today I had to chair a meeting. No anxiety was there. No gasping for breath occurred. No pronounced stuttering also occurred. However, I felt little bit of vocal blocks when try to speak. But, once I started, then there was no stuttering. In a meeting, whenever, I had to interrupt a talking person, I felt some vocal blocks. So, I kept quiet. Otherwise, my stuttering was manageable. I cracked some jokes also.