Effects of Methylfolate in combination with other nutrients

I took methylfolate along with other nutrients for fine tuning the benefits of methylfolate.

	L-methylfolate 7.5 mg/day (3.25 mg in morning and 3.25 mg in night) + Pyridoxine HCl 10 mg/day (5 mg in morning and 5 mg in night) + methylcobalamin 500 microgram/day (500 microgram in morning)	L-methylfolate 7.5 mg/day (3.25 mg in morning and 3.25 mg in night) + one capsule of Supradyn recharge in morning + methylcobalamin 500 microgram/day (500 microgram in morning) + Pyridoxine HCl 5 mg in night	L-methylfolate 7.5 mg/day (3.25 mg in morning and 3.25 mg in night) + one capsule of Supradyn recharge in morning + methylcobalamin 500 microgram/day (250 microgram in morning and 250 microgram in night)	L-methylfolate 7.5 mg/day (3.25 mg in morning and 3.25 mg in night) + one tablet of zincovit in morning + methylcobalamin 500 microgram/day (250 microgram in morning and 250 microgram in night) + one tablet of Calcium & Magnesium Plus (Elemental calcium 275.9 mg + elemental magnesium 125 mg + elemenatl manganese 1.5 mg + elemental zinc 300 microgram + Vitamin D3 100 IU)
Effects on anxiety	No anxiety	No anxiety	No anxiety	No anxiety
Effects on depression	No depressive feelings	No depressive feelings	No depressive feelings	No depressive feelings
Effects on stuttering and voice	Mild stuttering. Can make a fluent conversatioatin. No effect on loudness of voice	Less stuttering. Can make a fluent conversation. Good loudness of voice	Less stuttering. Can make a fluent conversation. Good loudness of voice	Less stuttering. Can make a somewhat fluent conversation. moderate loudness of voice
Effects on motivation	Slightly reduced Motivation	Reduced Motivation	Average motivation;. If methylcobalamin dose in increased, it produces less motivation and lethargic effects similar to that of fluoxetine. If methylfolate dose is increased, it creates increased motivation and restlessness.	Average motivation
Effects on concentration	Slightly reduced concentration throughout the day	Reduced concentration throughout the day	Slightly reduced concentration throughout the day	Average concentration
Effects on memory	Good	Good	Good
Effects on mental fog and clarity of thinking	Slightly reduced clarity of thinking	Reduced clarity of thinking	Nil to Slightly reduced clarity of thinking
Effects on telephonic conversation	Mild stuttering	Mild stuttering	Less stuttering and good speech
Effects on affection and social life	Neutral	Reduced affection towards family	Neutral
Effects on sleep	Not excessive sleepiness. Able to get up early in morning	Excessive sleepiness. Not able to get up early in morning, Uncontrollable sleeping after lunch in evening	Neutral
Effects on libido and sex	Neutral	Neutral	Neutral	seems to increase libido...gives good spontaneous erections...able to get strong erection after massaging for masturbation (this effect was better observed with medimix soap/chandrika soap). The soap is used for bathing only and not during the time of masturbation.
Effects on eye vision	Neutral	Neutral	Neutral
Effects on driving	Neutral	Neutral	Neutral
Effects on body temperature and sweating	Slightly increased sweating	Slightly increased sweating	Reduced body temperature and sweating
Other effects	Slight bad taste in mouth, mild skins rashes like an allergic reaction (red skin eruptions appear in line)	Slight bad taste in mouth, mild skins rashes like an allergic reaction (red skin eruptions appear in line)	No bad taste in mouth. No skin allergies. (If the tablets are taken after food)
Diet during these time	Oats porridge in morning and night; lunch – rice with 200 g of chicken or fish with 200 g vegetables	Oats porridge in morning and night; lunch – rice with 200 g of chicken or fish with 200 g vegetables	Oats porridge in morning and night; lunch – rice with 200 g of chicken or fish with 200 g vegetables

Effect of fluoxetine and supradyn recharge

Although I could achieve better results with the previous treatment plans I and II, still I had stuttering while talking on phone and to strangers. Sometimes the telephonic conversation occupy vital part of talking (like transaction negotiation or making an appointment) and stuttering at those timings gave me very worst embarassing.

So, I wanted to try fluoxetine again.

I took fluoxetine 20 mg once daily in the morning along with executive B multivitamin tablets. This combination gave me the following.

Positive effects:

• Moderate energy and motivation
• No effect on sexual function (good erections and good libido)
• Less stress, anxiety and depression

Negative effects:

• More pronounced stuttering.
• Heavily sleepy during day time especially after lunch.
• Heavy and profuse sweating.

Mechanism explanation:

• The Executive B multivitamin contains pyridoxine (Vit. B6) 10 mg. This amount might have catalysed the synthesis of huge quantity of serotonin.
• Increased serotonin synthesis might have led to increased 5-HT neurotransmission and subsequently increased dopamine neurotransmission in the speech area of brain thus producing more stuttering. 

So, I decided to reduce the amount of Vit. B6. Supradyn recharge naturally came as a first choice since it contained 5 mg of Vit. B6. So, I took fluoxetine 20 mg and supradyn recharge 1 capsule in the morning after breakfast. It produced less stuttering in the evening and more sleepiness and stuttering in the morning. Then I decided to change the timing of these two drugs. I took fluoxetine in the night after dinner and supradyn recharge capsules in the morning after breakfast. This combination produced wonderful effects on my stuttering.

Positive effects:

• Almost no stuttering and very clear speech except for the rare occurrence of mispelt words.
• Good loudness of voice without gasping for breath.
• Greater reduction of anxiety
• No feelings of depression - no negative feelings and worrying
• Very good judgement of space while driving car.
• Very good memory recall of routes while driving.
• Good sense of well being
• Almost no effect of food on stuttering - earlier if i consume protein in the lunch, my stuttering used to be worse. Now, whatever food I consmed did not affect my stuttering. So, I removed restrictions on my food type.
• Good sleep in the night.
• Good self control.
• Good control of blood pressure - 128/87 mm Hg with 86 pulse rate.

Negative effects:

• Motivation to start and remain in a task is reduced significantly
• Concentration to sustain in a task is also reduced significantly.
• Libido is also reduced significantly. But erections used to be slow onset and not much of a problem. Orgasm was delayed or did not occur in some instances. Libido was increased if supradyn recharge was not taken in the morning.
• Heavy and profuse sweating.
• Music is not enjoyable as before.

Suggestions:

• Either Vitamin C or DL-phenylalanine may be added in the morning or in the lunch time to increase concentration and motivation. However, care should be taken not to disturb the achieved fluency levels.  

Effects of Himalaya's geriforte

I am taking himalaya's geriforte for the past few days. And as usually, I found my anxiety is low and my stuttering is very minimal. Fluency of speech is excellent with good diction. From the literature, I found that geriforte may work through steroid receptors in the body.

I assume that my cortisol levels are low than the normal. (Even though the laboratory test results indicate the normal results. 1. I tested at Malar hospital, Chennai at 10 am after a coconut oil full body massage and steam bath at a naturopath's clinic (No breakfast, had only tea), tested in blood 2. Test done by neurogistics, US with saliva samples.) Since I experience everyday social anxiety stress due to my stuttering, I expect my cortisol levels to be higher than normal.

Also, based on the research literature, my LC-NE (locus ceroleus-norepinephrine) circuit seems to be high. Due to that, I used to have slightly elevated BP always (130/90). My cortisol levels should be lower than normal due to the continuous increased LC-NE activity. Due to everyday stress, my cortisol may appear to be normal (It could be actually an increase from the lower level).

After taking geriforte for few days, I tested my BP. Surprisingly, my BP was lower around 120/80 on repeated readings. Also, it increased my fluency to a greater level. From these things, I can assume that geriforte may work on corticosteroid receptors. Because glucocorticoids are known to reduce the LC-NE firing. Also, I experienced reduction of anxiety and stress.

Also I am taking a baby milk formula which contains tryptophan and tyrosine along with omega 6 and omega 3. I use this milk powder for making my milk tea. After taking this I don't find any greater influence of serotonergic effects like intense nausea. Also, the phenylalanine or tyrosine related effects like increased BP or increased stuttering or presyncope (about to faint feelings) or increased limb movements while walking. I assume that geriforte may normalize the HPA axis by reducing the LC-NE activity and decrease the impaired negative feedback of cortisol at the HPA axis.

Also, I experienced side effects after taking this medicine. gasping for breath while talking (bronchoconstriction), bloated stomach, blurred vision and some unusual irritating feeling inside my head (I don't know how to express this symptom and this symptom is completely stopped after I took magnesium with glycine and taurine, so it could be increased glutamate activity) which produced restlessness. The bronchoconstriction effect subsided slowly after few doses. Blurred vision is worsened with stress (when I was driving to a new place, blurred vision occurred and it didn't subside even after resting for few hours and eating lunch, after sleeping only it subsided). So, the blurred vision could be also due to increased epinephrine release during the stress.

So based on the adverse effects of this drug, the mechanism of action could be through cholinergic system. I read one literature that ashwagandha acts through inhibition of acetylcholine esterase. This could be the possible reason for blurred vision.

Also, I found that my fecal incontinence is much better now. So, it could have been caused by the weaker sphincter muscle which is again caused by a low acetylcholine level.