Effects of Methylfolate in combination with other nutrients

I took methylfolate along with other nutrients for fine tuning the benefits of methylfolate.

	L-methylfolate 7.5 mg/day (3.25 mg in morning and 3.25 mg in night) + Pyridoxine HCl 10 mg/day (5 mg in morning and 5 mg in night) + methylcobalamin 500 microgram/day (500 microgram in morning)	L-methylfolate 7.5 mg/day (3.25 mg in morning and 3.25 mg in night) + one capsule of Supradyn recharge in morning + methylcobalamin 500 microgram/day (500 microgram in morning) + Pyridoxine HCl 5 mg in night	L-methylfolate 7.5 mg/day (3.25 mg in morning and 3.25 mg in night) + one capsule of Supradyn recharge in morning + methylcobalamin 500 microgram/day (250 microgram in morning and 250 microgram in night)	L-methylfolate 7.5 mg/day (3.25 mg in morning and 3.25 mg in night) + one tablet of zincovit in morning + methylcobalamin 500 microgram/day (250 microgram in morning and 250 microgram in night) + one tablet of Calcium & Magnesium Plus (Elemental calcium 275.9 mg + elemental magnesium 125 mg + elemenatl manganese 1.5 mg + elemental zinc 300 microgram + Vitamin D3 100 IU)
Effects on anxiety	No anxiety	No anxiety	No anxiety	No anxiety
Effects on depression	No depressive feelings	No depressive feelings	No depressive feelings	No depressive feelings
Effects on stuttering and voice	Mild stuttering. Can make a fluent conversatioatin. No effect on loudness of voice	Less stuttering. Can make a fluent conversation. Good loudness of voice	Less stuttering. Can make a fluent conversation. Good loudness of voice	Less stuttering. Can make a somewhat fluent conversation. moderate loudness of voice
Effects on motivation	Slightly reduced Motivation	Reduced Motivation	Average motivation;. If methylcobalamin dose in increased, it produces less motivation and lethargic effects similar to that of fluoxetine. If methylfolate dose is increased, it creates increased motivation and restlessness.	Average motivation
Effects on concentration	Slightly reduced concentration throughout the day	Reduced concentration throughout the day	Slightly reduced concentration throughout the day	Average concentration
Effects on memory	Good	Good	Good
Effects on mental fog and clarity of thinking	Slightly reduced clarity of thinking	Reduced clarity of thinking	Nil to Slightly reduced clarity of thinking
Effects on telephonic conversation	Mild stuttering	Mild stuttering	Less stuttering and good speech
Effects on affection and social life	Neutral	Reduced affection towards family	Neutral
Effects on sleep	Not excessive sleepiness. Able to get up early in morning	Excessive sleepiness. Not able to get up early in morning, Uncontrollable sleeping after lunch in evening	Neutral
Effects on libido and sex	Neutral	Neutral	Neutral	seems to increase libido...gives good spontaneous erections...able to get strong erection after massaging for masturbation (this effect was better observed with medimix soap/chandrika soap). The soap is used for bathing only and not during the time of masturbation.
Effects on eye vision	Neutral	Neutral	Neutral
Effects on driving	Neutral	Neutral	Neutral
Effects on body temperature and sweating	Slightly increased sweating	Slightly increased sweating	Reduced body temperature and sweating
Other effects	Slight bad taste in mouth, mild skins rashes like an allergic reaction (red skin eruptions appear in line)	Slight bad taste in mouth, mild skins rashes like an allergic reaction (red skin eruptions appear in line)	No bad taste in mouth. No skin allergies. (If the tablets are taken after food)
Diet during these time	Oats porridge in morning and night; lunch – rice with 200 g of chicken or fish with 200 g vegetables	Oats porridge in morning and night; lunch – rice with 200 g of chicken or fish with 200 g vegetables	Oats porridge in morning and night; lunch – rice with 200 g of chicken or fish with 200 g vegetables

Effects of methylfolate

I took 5 mg of folic acid per day (2.5 mg in morning and 2.5 in night). I felt more energetic and motivated. So, I have started experimenting with methylfolate.

	L-methylfolate 7.5 mg/day (3.25 mg in morning and 3.25 mg in night) + one zincovit tablet  in morning + one Magcalzinc tablet in night (Elemental calcium 250 mg + Elemental magnesium 125 mg + elemental zinc 3 mg)	L-methylfolate 7.5 mg/day (3.25 mg in morning and 3.25 mg in night) + one zincovit tablet  in morning	L-methylfolate 7.5 mg/day (3.25 mg in morning and 3.25 mg in night)	L-methylfolate 7.5 mg/day (3.25 mg in morning and 3.25 mg in night) + one capsule of fluoxetine in night
Effects on anxiety	No anxiety	No anxiety	No anxiety	No anxiety
Effects on depression	No depressive feelings	No depressive feelings	No depressive feelings	No depressive feelings
Effects on stuttering and voice	Moderate stuttering was there. Cannot make a fluent conversation. Reduced loudness of voice	Moderate stuttering was there. Cannot make a fluent conversation. Reduced loudness of voice	Moderate to severe stuttering was there. Cannot make a fluent conversation or presentation. Reduced loudness of voice	Much reduced stuttering. Can make a good presentation and conversation. Good loudness of voice
Effects on motivation	Good motivation	Good motivation	Good motivation	Reduced motivation and increased lethargy
Effects on concentration	Good concentration throughout the day	Good concentration throughout the day	Good concentration on tasks in morning. Low concentration in afternoons. Then, concentration increases after 7 pm.	Reduced concentration
Effects on memory	Good	Good	Good	Good
Effects on mental fog and clarity of thinking	Good	Good	Good	Reduced clarity of thinking
Effects on telephonic conversation	Moderate stuttering	Moderate stuttering	Moderate stuttering	Reduced stuttering
Effects on affection and social life	Longing for love from family members but no interest in social life	Longing for love from family members but no interest in social life	Longing for love from family members but no interest in social life	Reduced affection towards family but increased participation in social gatherings probably due to less stuttering
Effects on sleep	No excessive sleepiness. Able to get up early in morning	No excessive sleepiness. Able to get up early in morning	Not much of excessive sleepiness. But, heavy uncontrollable sleepy feeling after taking lunch.	Increased sleepiness. Cannot get up easily in morning.
Effects on libido and sex	Neutral	Neutral	Neutral	Neutral to less
Effects on eye vision	Neutral	Neutral	Neutral	Neutral
Effects on driving	Neutral	Neutral	Neutral	Neutral
Effects on body temperature and sweating	No ‘heated body’ feeling and no increased sweating	No ‘heated body’ feeling and no increased sweating	No ‘heated body’ feeling and no increased sweating	Increased sweating
Other effects	Moderate right hand wrist pain and forearm pain was there due to excessive computer mouse usage, bad taste in mouth, mild skins rashes like an allergic reaction (red skin eruptions appear in line)	Mild right hand wrist pain and forearm pain was there due to excessive computer mouse usage, bad taste in mouth, mild skins rashes like an allergic reaction (red skin eruptions appear in line)	No hand pain or wrist pain, bad taste in mouth, bad breath, mild skins rashes like an allergic reaction (red skin eruptions appear in line)	Slight bad breath, mild skins rashes like an allergic reaction (red skin eruptions appear in line)
Diet during these time	Oats porridge in morning and night; lunch – rice with 200 g of chicken or fish with 200 g vegetables	Oats porridge in morning and night; lunch – rice with 200 g of chicken or fish with 200 g vegetables	Oats porridge in morning and night; lunch – rice with 200 g of chicken or fish with 200 g vegetables	Oats porridge in morning and night; lunch – rice with 200 g of chicken or fish with 200 g vegetables

Link between working memory, stress, anxiety, depression and stuttering

Working memory in human beings can be analogous to the computer RAM. More the RAM a computer has, faster the computer is. Having more RAM in a computer can help the computer to perform faster operations and multitasking. Similarly, availability of more working memory in humans will enable to do better multitasking at faster speeds.

For the past 4 days I am taking Ginkgo biloba 2500 mg extract. Also, I am walking 30 minutes everyday evening around 8 - 9 pm.

Composition:
Each capsule contains 50 mg of standardized extract (equivalent to 2500 mg of dry Ginkgo biloba leaves); contains 24% ginkgoflavonglycosides and 6% terpene lactones.

Positive effects:

• Good mood - really good mood with inflow of innate happiness
• Very less anxiety - anxiety was extremely less while speaking
• Almost no stuttering - very good fluency with more talkative nature; No anxiety while calling through phone.
• Increased libido - With good inflow of happiness, I am in a mood to look forward for sex. However, not strong erections.
• No headaches - really no headaches and my head is really very clear
• Able to get ready faster in the morning - around 1 hour to 1 hour 15 minutes. Before, it used to be 1 hour 30 minutes.
• My car driving speed increased tremendously. I am able to drive at 110-120km/h speed and at the same time enjoying music. (Earlier, whenever I accelerate to 110-120km/h speed, all my attention used to focus on driving and on the road. And also, I used to feel my adrenaline rush. Whenever car used to shake due to road imperfections, my adrenaline increased and all my attention focused on road and steering wheel). But, now, I am least bothered about the car shake and able to enjoy music. 2 days back, I was driving in the fast lane at 110-120km/h speed. I made 3 cars to change to slower lane to give me way, which were going in front of me. Such a tremendous speed of information processing never happened to me before while driving.
• Music is enjoyable very much.
• I have started watching movies also. Earlier, I lose patience in watching movies continuously.
• Able to make phone calls to relative without much stuttering and anxiety. This was not at all possible before. Earlier, I used to have fear of stuttering and anxiety of talking over phone. Due to this, I avoided calling my relatives which led to some misunderstanding amongst my relatives.  

Negative effects:

• More sleepy - sleeping time increased to 8-10 hours.
• Not very strong erections. But sustained increase in libido is observed. This libido seems to be linked with dopamine levels. Actually before taking this Ginkgo biloba, I was taking bupropion SR 150 mg for four days. Then I stopped it for 1 day. Then, the next day, I took this Gingko biloba. So, the residual bupropion remained in the body would have caused this increased libido possibly.

Neutral effects:

• Not significant increase in speed of working - but slightly increased motivation to remain in a task is observed. Still inertia to initiate the planned work is there.

Update on 27 June 2012:

• Today I had to chair a meeting. No anxiety was there. No gasping for breath occurred. No pronounced stuttering also occurred. However, I felt little bit of vocal blocks when try to speak. But, once I started, then there was no stuttering. In a meeting, whenever, I had to interrupt a talking person, I felt some vocal blocks. So, I kept quiet. Otherwise, my stuttering was manageable. I cracked some jokes also.

Corticosteroids, anxiety and depression

Effect of Prednisolone

Today I took corticosteroid prednisolone 5 mg in the morning (only prednisolone, no other supplements). I just wanted to compare the effects of prednisolone to that of geriforte. As I expected, prednisolone produced similar effect like geriforte.

Positive effects:

1. Improved sense of general well being
2. No unsteadiness while walking and no vertigo
3. Decreased perception of heat and hot spicy food (chillies) -  due to anti-inflammatory effects

Negative effects:

1. No improvement on stuttering
2. My voice is not louder with lack of deep bass notes. My voice sounds like a voice of a person who gave lecture for many hours continuously.

So, from these observation of the symptoms, I could make out that geriforte may contain a chemical which could act on the corticosteroid receptors in the CNS. It could be an low dose synthetic corticosteroid or could be a natural steroid resembling compound glycyrrhizin from Glycyrrhiza glabra (licorice, liquorice, yastimadhu, athimathuram) or could be phytosterols.

In the evening, I got mild headache, resembling low serotonin-induced headache. So, I could feel that after taking geriforte for about 10 days and prednisolone for 1 day, the cumulative effects of steroids (increased steroid levels) would have suppressed my serotonin levels and due to that I might have got headache.

So, this observation indicates that increased cortisol level during stress would decrease the serotonin levels. It may

• decrease the serotonin release or 
• decrease the serotonin receptor 5-HT1A or 
• decrease the serotonin transporter or 
• increase the metabolism of serotonin

Update on 06 October 2015

Effect of Betamethasone valerate:

Composition of Betnovate-N cream:

The main active ingredient - betamethasone (as valerate) 0.1%
an antibacterial agent - neomycin sulphate 3%
a preservative - chlorocresol
in a base containing cetomacrogol 1000, white soft paraffin, and liquid paraffin.
The cream does not contain any lanolin, parabens or colouring agents. 


I applied betnovate-N cream on my face and neck for some red eruptions in the night around 1.30 am before going to sleep. The next morning, I could get up around 8 am without any lethargy and I could do more work with sustained focus and concentration. This focus and concentration was enhanced by taking vitamin C 500 mg in the morning after breakfast. This enhanced focus and concentration sustained even until late night.

When I applied the cream in the morning after I get up around 8 am, it produced unpleasant effects. I could not have sustained focus and concentration. It increased stuttering with reduced volume while speaking.

When I applied the cream at 9 pm in night, I could sleep without much disturbance. But while getting up next morning, I felt lethargic and tired. But after arriving at office, I could sustain focus and concentration in my work until evening.

While I applied this cream during night, I experienced vivid dreams. Some are frightening. In some dreams, I used to get angry. Even though the sleep appeared to be full of dreams, I used to get the well-slept feeling after waking up.

I am planning to try this strategy for next 3 weeks to regulate my cortisol levels. It appears that I have either low cortisol level or hypoactive HPA axis.