Effects of methyl cobalamin

For the last three months, I am not taking any multivitamins. I have developed right hand pain (due to laptop mouse usage), low back pain (probably due to poor sitting posture and sleeping on foam mattress which forms body impressions) and gluteal muscles pain (probably due to poor sitting posture). So, I tried taking methylcobalamin 500 micrograms once daily for 4 days (two days taken at night and two days taken at morning).

Positive effects:

1. Reduction of hand pain and low back pain
2. Little relaxed mind
3. Tendency to watch movies, listen to music

Negative effects:

1. Not getting sleep in the night - but if I sleep, unable to get up easily.
2. No focus or concentration to do any job - simple jobs took may hours to complete
3. No motivation and energy to do any job.
4. Not able to think deeply - postponement of few tasks

5. No attention to details - errors happened in work

6. Decreased speed of information processing while driving


30 hours after the last dose of methylcobalamin, I felt return of energy and focus.

Severe headache and ibuprofen

I had severe headache after consumption of becosules Z capsules (just one dose) and applying betnovate N cream for two days. The severe headache may be due to the presence of 100 mg of niacinamide in becosules z capsules. I used to get headache while I was taking niacin before. The headache was right sided indicating that it may be dopamine deficiency-induced. I took 400 mg ibuprofen at midnight. After 40 minutes, the headache disappeared and slept nicely. Earlier, I used to take dicolofenac for such headaches or paracetamol. Diclofenac used to be very effective but due to its enteric coating, it will work after 4 hours only. Paracetamol 650 mg or 1 gm may afford some relief with residual mild headache continuing for next 1-2 days. Ibuprofen seems to be effective. But, I had some stomach discomfort after taking the tablet indicating its ulcerogenic potential.

Effects of egg consumption, abstinence from multivitamin and milk consumption and meat consumption on hand pain

For the past 3-4 months, I have stopped all multivitamins. For the past 20 days (during the fasting month) to 1 month, I have been consuming two eggs per day (one at breakfast and another one at dinner). Also, I have consumed mainly wheat based items for past 15 days.

Positive effects:

1. Reduced anxiety and feelings of joy happened after stopping the fasting. This lasted for few days and start to decrease after that.
2. Reduced stuttering and gasping for breath while talking
3. Increased libido, strong erections, enhanced feeling of orgasm.

Negative effects:

1. Unable to sustain focus or concentration on research related work (review and writing of papers).
2. Reduced productivity in terms of research related work.
3. Hand pain, lower back pain and buttock muscles pain (gluteal muscle) slowly start to occur after 3 months of abstinence from multivitamins. Sometimes, the pain gives much discomfort in continuing the computer work.

Milk consumption:

1. These negative effects are almost overcome by the consumption of full cream milk at night just before going to bed. Half a glass full cream milk was consumed after 4 hours of dinner and just before to lie on bed. Next morning, higher energy levels, positive mood, increased focus and concentration were observed. This effect was observed with all dairy products such as milk, yoghurt, butter and ghee except cheese. However, the pain component stayed there. Not much change was observed in the hand pain, finger pain, low back pain and buttock muscle pain.

Hand pain and meat consumption:

Due to heavy laptop use with mouse, I used to get right hand pain around the wrist, palm and fingers. With rest, this pain usually subsides. Sometimes, the pain is severe. Nowadays, I am not taking any multivitamin. But, I am consuming two eggs per day one in the lunch and dinner. Still, the hand pain is there almost everyday. With rest (not using laptop and mouse), the pain disappears. After consumption of meat (mutton, beef and chicken with mutton being the most significant influencer and chicken the least), I have observed that the pain subsides significantly. Also, this hand pain also subsides after consumption of calcium, magnesium, zinc tablet. These observations suggest that the meat products may contain these minerals and might offer the reduction of hand pain. However, the amount of calcium and zinc in mutton and beef meat are not really that much. So, alternatively, based on my previous experiences, the role of vitamin B12 may be suspected here as meat products especially mutton and beef contain more B12 and might offer some neurological cure to hand pain.

Update on hand pain 2 July 2020:

The hand pain decreased very much after I stopped egg consumption for two days. I am taking osteocare tablets and diabetone capsules every day. Need to analyse which one has reduced the hand pain.

Update on hand pain 25 July 2020:

I have taken magnesium at night after dinner (200 mg of magnesium from vitabiotics brand; They have not mentioned what form of magnesium is present in the tablet) for last few days and found my muscle pain and hand pain decreased substantially. However, the focus and concentration decreased very much with magnesium consumption at night.

Effects of Rasagiline

I have taken Rasagiline 0.5 mg once daily in morning after breakfast for three days. For the last one week, I was not taking any multivitamin tablets.
 

Positive effects:

1. Less anxiety
2. Less stuttering - Less gasping for breath while speaking, slightly increased loudness of voice
3. Less sleepiness after lunch; even in the night also, no complete sleep
4. Music is enjoyable

Neutral effects:

1. No significant improvement in focus, concentration and energy
2. No significant improvement in libido

Negative effects:

1. Slight insomnia
2. Slight postural instability

Treatments / therapies to try

1. Take benzodiazepine (alprazolam) for 1 - 2 months. Then, stop. It may cause increased drive of noradrenaline and dopamine. I used to take this combination in 2000 before joining the job. It increased the libido and affection tremendously.

2. Take 2 - 4 eggs (preferably half boiled) daily for 2 months. It increased libido and erection strength.

3. Go for walking 45 minutes two times (preferably one in morning and one in evening) daily.

4. Stop drinking tea and coffee. Take green tea with brown sugar or honey two times daily. Avoid white sugar. Avoid eating rice. Consume wheat based products only. Take thiamine 25 mg two times daily. I did this during Ramadhan fasting and found no stuttering and gasping for breath. Not much of sleepiness also.

5. Take folic acid, vitamin B12 and vitamin A and vitamin C to avoid peripheral neuropathy symptoms.

Deficiency of Alpha-Linolenic acid causes disturbances in dopaminergic neurotransmission

More and more reports in recent years have shown that the intake of polyunsaturated fatty acids (PUFA) constitutes an environmental factor able to act on the central nervous system (CNS) function. We recently demonstrated that the effects of PUFA on behavior can be mediated through effects on the monoaminergic neurotransmission processes. Supporting this proposal, we showed that chronic dietary deficiency in alpha-linolenic acid in rats induces abnormalities in several parameters of the mesocortical and mesolimbic dopaminergic systems. In both systems, the pool of dopamine stored in presynaptic vesicles is strongly decreased. This may be due to a decrease in the number of vesicles. In addition, several other factors of dopaminergic neurotransmission are modified according to the system affected. The mesocortical system seems to be hypofunctional overall [e.g., decreased basal release of dopamine (DA) and reduced levels of dopamine D2 (DAD2) receptors]. In contrast, the mesolimbic system seems to be hyperfunctional overall (e.g., increased basal release of DA and increased levels of DAD2 receptors). These neurochemical changes are in agreement with modifications of behavior already described with this deficiency. The precise mechanisms explaining the effects of PUFA on neurotransmission remain to be clarified. For example, modifications of physical properties of the neuronal membrane, effects on proteins (receptors, transporters) enclosed in the membrane, and effects on gene expression and/or transcription might occur. Whatever the mechanism, it is therefore assumed that interactions exist among PUFA, neurotransmission, and behavior. This might be related to clinical findings. Indeed, deficits in the peripheral amounts of PUFA have been described in subjects suffering from neurological and psychiatric disorders. Involvement of the monoaminergic neurotransmission function has been demonstrated or hypothesized in several of these diseases. It can therefore be proposed that functional links exist among PUFA status, neurotransmission processes, and behavioral disorders in humans. Animal models are tools of choice for the understanding of such links. Improved prevention and complementary treatment of neurological and psychiatric diseases can be expected from these studies.

Reference:

Polyunsaturated fatty acids and cerebral function: focus on monoaminergic neurotransmission.

Omega-3 fatty acids and monoamine neurotransmission.

Dietary fish oil affects monoaminergic neurotransmission and behavior in rats.