I am taking himalaya's geriforte for the past few days. And as usually, I found my anxiety is low and my stuttering is very minimal. Fluency of speech is excellent with good diction. From the literature, I found that geriforte may work through steroid receptors in the body.
I assume that my cortisol levels are low than the normal. (Even though the laboratory test results indicate the normal results. 1. I tested at Malar hospital, Chennai at 10 am after a coconut oil full body massage and steam bath at a naturopath's clinic (No breakfast, had only tea), tested in blood 2. Test done by neurogistics, US with saliva samples.) Since I experience everyday social anxiety stress due to my stuttering, I expect my cortisol levels to be higher than normal.
Also, based on the research literature, my LC-NE (locus ceroleus-norepinephrine) circuit seems to be high. Due to that, I used to have slightly elevated BP always (130/90). My cortisol levels should be lower than normal due to the continuous increased LC-NE activity. Due to everyday stress, my cortisol may appear to be normal (It could be actually an increase from the lower level).
After taking geriforte for few days, I tested my BP. Surprisingly, my BP was lower around 120/80 on repeated readings. Also, it increased my fluency to a greater level. From these things, I can assume that geriforte may work on corticosteroid receptors. Because glucocorticoids are known to reduce the LC-NE firing. Also, I experienced reduction of anxiety and stress.
Also I am taking a baby milk formula which contains tryptophan and tyrosine along with omega 6 and omega 3. I use this milk powder for making my milk tea. After taking this I don't find any greater influence of serotonergic effects like intense nausea. Also, the phenylalanine or tyrosine related effects like increased BP or increased stuttering or presyncope (about to faint feelings) or increased limb movements while walking. I assume that geriforte may normalize the HPA axis by reducing the LC-NE activity and decrease the impaired negative feedback of cortisol at the HPA axis.
Also, I experienced side effects after taking this medicine. gasping for breath while talking (bronchoconstriction), bloated stomach, blurred vision and some unusual irritating feeling inside my head (I don't know how to express this symptom and this symptom is completely stopped after I took magnesium with glycine and taurine, so it could be increased glutamate activity) which produced restlessness. The bronchoconstriction effect subsided slowly after few doses. Blurred vision is worsened with stress (when I was driving to a new place, blurred vision occurred and it didn't subside even after resting for few hours and eating lunch, after sleeping only it subsided). So, the blurred vision could be also due to increased epinephrine release during the stress.
So based on the adverse effects of this drug, the mechanism of action could be through cholinergic system. I read one literature that ashwagandha acts through inhibition of acetylcholine esterase. This could be the possible reason for blurred vision.
Also, I found that my fecal incontinence is much better now. So, it could have been caused by the weaker sphincter muscle which is again caused by a low acetylcholine level.