Effect of St. John's wort + Bupron (Bupropion SR) - 150 mg

Due to the tiredness I felt after taking St. John's wort for 1 month, I thought of adding bupropion SR 150 mg.  I  took the combination only on one day.


Positive effects:

• Slightly improved energy
• A long pause before starting the speech which made me embarrassed in the meeting. subsequently it led me to sink in negative thoughts.

Negative effects:

• Low mood in the evening
• Depressive thoughts and thoughts about death ("death is the only solution")

With single dose, no conclusion can derived. The combination can be tried for few more days.

Effect of St. John's Wort

For the last 1 month I took St. John's wort 300 mg, (Kordel’s St. John's Wort 300mg), standardized to contain 0.3% of hypericin.

 

Positive effects:

• No Depressive negative thoughts
• Reduced anxiety - but this reduction is lesser than that experienced with bupropion.
• Slightly strong erections
• Stuttering was mild and I could overcome that
• Not much of sleepiness. Reduced hypersomnia.

Negative effects:

• Pronounced tiredness
• Lack of focus and concentration
• Lack of motivation - unable to initiate work

Interpretation:

• Pronounced GABA agonism effect which might have subsequently decreased dopamine
• Less agonism effect on serotonergic system.