Composition of Supradyn Recharge Multivitamin Capsules (Bayer)

Each capsule contains
	Quantity	% US RDA
12 Vitamins
Vitamin A (1 mg)	3333 I.U.	100
Vitamin B1	4.5 mg	300
Vitamin B2	5.1 mg	300
Vitamin B6	6 mg	300
Vitamin B12	6 mcg	300
Vitamin C	180 mg	300
Vitamin D3 (3 mcg)	200 I.U.	100
Vitamin E	10 mg	100
Biotin	0.3 mg	100
Pantothenic acid	21 mg	200
Folic acid	0.2 mg	100
Nicotinamide	57 mg	350
8 Minerals and trace elements
Calcium	50 mg	5
Magnesium	40 mg	10
Phosphorus	50 mg	5
Chromium	10 mcg	8
Copper	0.4 mg	20
Iron	3.6 mg	36
Manganese	0.5 mg	14
Zinc	3 mg	20

Composition of Centrum multivitamin tablets

Centrum® Tablets

	Supplement Facts
	Serving Size 1 Tablet
	Each Tablet Contains	% Daily Value
	Vitamin A 3500 IU (29% as Beta-Carotene)	70%
	Vitamin C 60 mg	100%
	Vitamin D 400 IU	100%
	Vitamin E 30 IU	100%
	Vitamin K 25 mcg	31%
	Thiamin 1.5 mg	100%
	Riboflavin 1.7 mg	100%
	Niacin 20 mg	100%
	Vitamin B6 2 mg	100%
	Folic Acid 400 mcg	100%
	Vitamin B12 6 mcg	100%
	Biotin 30 mcg	10%
	Pantothenic Acid 10 mg	100%
	Calcium 200 mg	20%
	Iron 18 mg	100%
	Phosphorus 20 mg	2%
	Iodine 150 mcg	100%
	Magnesium 50 mg	13%
	Zinc 11 mg	73%
	Selenium 55 mcg	79%
	Copper 0.5 mg	25%
	Manganese 2.3 mg	115%
	Chromium 35 mcg	29%
	Molybdenum 45 mcg	60%
	Chloride 72 mg	2%
	Potassium 80 mg	2%
	Boron 75 mcg	*
	Nickel 5 mcg	*
	Silicon 2 mg	*
	Tin 10 mcg	*
	Vanadium 10 mcg	*
	* Daily Value not established.

Source: http://www.centrum.com/productdetail.aspx?BrandProductId=40

My perceived neurocircuitary diagram

My condition is a combination of atypical depression caused by occupational social anxiety problem caused by persistent stuttering problem. So, stuttering is the root cause of my problem. Even though I overcome my stuttering during my adolescent ages, change of situations and change of language use posed greater amount of inescapable stress from the prevailing situations. This had continuously impaired my neurocircuitary resulted in worsened social anxiety with atypical depression.

Constant psychological stress caused increased corticotropin releasing hormone (CRH) from pituitary. Increased CRH caused increased cortisol levels which subsequently reduced the serotonin receptors. Also, increased CRH release might have caused increased glutamatergic and noradrenergic neurotransmission. Increased glutamatergic drive might have caused exhausted dopamine system and reduced GABA levels. Increased NA levels also might cause decreased GABA and 5-HT levels.

Also, my urine analysis report from neurogistics indicated the following.

• Serotonin is OK.
• Cortisol release pattern is OK except a little low release in the evening.
• Glutamate is excessively released.
• Dopamine is excessively released.
• GABA is released in huge excessive.
• Noradrenaline is released in huge excessive
• Adrenaline is very low.

So, for me, it looks like, I have either increased CRH, increased ACTH but adrenal insufficiency. OR I may have normal CRH, normal/decreased ACTH, increased glutamate, increased dopamine and increased NE.

So, from the above diagram, it may be inferred that by reducing the CRH level all the stress axis can be normalized. As of now, there is no safe CRH antagonists available. So, the effective form of treatment could be reducing the increased glutamatergic drive and noradrenergic drive. To reduce glutamate neurotransmission, zinc, magnesium, taurine and folic acid can be used. To reduce noradrenergic neurotransmission, GABA agonists can be used.

Effect of Alprazolam SR (XANAX XR)

I took alprazolam SR (sustained release) 0.5 mg for the past 3 days. In these, three days, I did not take any multivitamin or any other drug or nutraceuticals. Also, for the past one week, I did not take any multivitamin formulations.

Positive effects:

• Reduced anxiety
• Able to concentrate on work and stay focused on work
• Generally good mood

Negative effects:

• Excessive sleepiness especially after lunch
• Loudness of voice was low
• Stuttering was there  - unable to complete the sentence - lack of breath control

Mechanism:
Probably increased dopaminergic neurotransmission and increased glutamate neurotransmission.