I experienced an unusual and unstutterable pause during my speech when I was taking certain supplements.
In 2008, I took Renerve capsules
http://www.grandix.in/products_neuro.html
The composition is given below. After taking this caps, I experienced this kind of stuttering for the first time. I speak faster and after 5-15 minutes, the unusual pause of 3- 7 seconds comes in. It is like an epilepsy attack (may be an absence seizure). During that pause, I was not able to make any sound from my throat. But, no loss of consciousness, no loss of memory and no impairment of other functions. And, no other symptoms also. I used to feel like paralysis of my vocal cord. I assume that this could be due to dopamine (either increased or decreased levels) or some minerals.
Products
| |
Packing
|
Composition
| |
| ReNerve | Soft
Gel
Caps | 10x10's | Methyl Cobalamin
Alpha Lipoic Acid
Vitamin E Acetate
Vitamin B1 HCl
Vitamin B6
Vitamin A Concentrate
Calcium Pantothenate
Selenium Dioxide
Folic Acid
Chromium polynicotinate
Inositol | 500 mcg
100 mg
25 mg
10 mg
1.5 mg
2500 IU
10 mg
163.6mcg
5 mg
200 mcg
100 mg |
The same effect was observed when I was taking neurogistics multivitamin capsules also. The composition is given below. Here, Vitamin B12 is present as methylcobalamin. So, it could be due to methylcobalamin. when I switched over to other vitamin tablets with Vitamin B12 as cyanocobalamin, this effect was not there. However, this effect could be due to some other component/mechanism also.
This effect was more observed during the time when I was taking DL-phenylalanine 1000 mg (500 mg X 2) daily in mornings. When I was taking this neurogistics multivitamin caps together with 5-HTP along with magnesium, taurine and glycine, this effect was not there. So, I assume the culprits as dopamine and methyl cobalamin. The clear mechanism is unknown. It could be a form of vocal cord dystonia induced by excess dopamine also.
I was taking
zincovit multivitamin tablets in 2008. That also caused this effect. But it was less severe. The worst was with neurogistics multivitamin + vitamin C + DL-phenylalanine.
Composition of zincovit tablets:
| Vitamins |
| Ascorbic acid as coated | 75 mg |
| Niacinamide | 50 mg |
| Alphatocopheryl Acetate concentrate (Powder form) | 15 mg |
| Thiamine mononitrate | 10 mg |
| Riboflavine | 10 mg |
| Calcium Pantothenate | 2 mg |
| Pyridoxine Hydrochloride | 2 mg |
| Folic aicd | 1 mg |
| Vitamin A con. Powder form (as acetate) | 5000 I.U. |
| VitaminD3 (Cholecalciferol) | 400 I.U. |
| Minerals |
| Zinc sulphate monohydrate | 63 mg |
| Magnesium oxide | 30 mg |
| Manganese sulpahte monohydrate | 2.8 mg |
| Copper sulphate | 2 mg |
| Colloidal Sillicon Dioxide (equ. To Sillica) | 1 mg |
| Pottassium Idodie (Eq. to Iodine) | 150 mcg |
| Sodium Borate (Equ. Boron) | 150 mcg |
| Selenium di oxide monohydrate | 70 mcg |
| Chromium picolinate (equ to Chromium) | 25 mcg |
| Sodium molybdate Dihydrate (equ to molybdenum) | 25 mcg |
(Source:
http://www.apexlab.com/html/zincovit.html)
Today, I had this effect when I was talking to my landlord (luckily she was counting the rental money I gave to her, So I had some time to observe my pause). Oh my God! What a horrible disturbances in this life? I took Vitamin C (500 mg
NOT slow release) + bioflavonoids and DL-phenylalanine 500 mg in the lunch time. Around 7 pm I had this effect.
Possible mechanism:
- Vitamin C increases noradrenaline synthesis and DL-phenylalanine increases noradrenaline, dopamine and adrenaline.
- I feel this increase may be an excess or there may not be a matching increase in serotonin and GABA. So I should try increasing serotonin (5-HTP) and GABA (Mentat)
Reduced effect of unstutterable stuttering - Update on 12 may 2010:
For the past few days, I am taking the supplements as follows:
Morning: 1 capsule of 5-HTP - 50 mg; 1 capsule of DL-phenylalanine - 500 mg, 2 capsules of neurogistics multivitamin; 1 tablet of l-lysine - 600 mg
Lunch/evening: 1 capsule of DL-phenylalanine 500 mg
Evening/night: 1 capsule of neurogistics multivitamin; 1 capsule of omega -3 (EPA + DHA = 780 mg)
Diet:
Morning - oats or noodles (not much of protein)
Lunch - rice, vegetables and 1 piece of fish
Dinner - rice or dosa with chicken drum stick 1 piece
This condition has reduced my unstutterable stuttering to greater level. Not much of longer pauses like before. I am not taking vitamin C and magnesium. They are said to have antidepressant properties but they may interact with noradrenergic and dopaminergic systems. I suspect the magneisum very much for this effect. Need to explore more on this area.
Ascorbic acid administration produces an antidepressant-like effect: Evidence for the involvement of monoaminergic neurotransmission
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 33, Issue 3, 30 April 2009, Pages 530-540.
Abstract
Ascorbic acid is highly concentrated in the brain, being considered as a neuromodulator. This study investigated the effect of ascorbic acid in the tail suspension test (TST) and in the forced swimming test (FST) in mice and the contribution of the monoaminergic system to its antidepressant-like effect. Moreover, the effects of fluoxetine, imipramine and bupropion in combination with ascorbic acid in the TST were investigated. Ascorbic acid (0.1-10 mg/kg, i.p., 1-10 mg/kg p.o. or 0.1 nmol/mice i.c.v.) produced an antidepressant-like effect in the TST, but not in the FST, without altering the locomotor activity. The effect of ascorbic acid (0.1 mg/kg, i.p.) in the TST was prevented by i.p. pre-treatment with NAN-190 (0.5 mg/kg), ketanserin (5 mg/kg), MDL72222 (0.1 mg/kg), prazosin (62.5 microg/kg), yohimbine (1 mg/kg), propranolol (2 mg/kg), haloperidol (0.2 mg/kg), sulpiride (50 mg/kg), but not with SCH23390 (0.05 mg/kg, s.c.). Additionally, ascorbic acid (1 mg/kg, p.o.) potentiated the effect of subeffective doses (p.o. route) of fluoxetine (1 mg/kg), imipramine (0.1 mg/kg), or bupropion (1 mg/kg) in the TST. The combined treatment of ascorbic acid with antidepressants produced no alteration in the locomotion in the open-field test. In conclusion, our results show that administration of ascorbic acid produces an antidepressant-like effect in TST, which is dependent on its interaction with the monoaminergic system. Moreover, ascorbic acid caused a synergistic antidepressant-like effect with conventional antidepressants. Therefore, the present findings warrant further studies to evaluate the therapeutical relevance of ascorbic acid for the treatment of depression and as a co-adjuvant treatment with antidepressants.
Evidence for the involvement of the monoaminergic system in the antidepressant-like effect of magnesium. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Mar 17;33(2):235-42. Epub 2008 Nov 27.
Abstract
Literature data has shown that acute administration of magnesium reduces immobility time in the mouse forced swimming test (FST), which suggests potential antidepressant activity in humans. However, its mechanism of action is not completely understood. Thus, this study is aimed at investigating the antidepressant-like action of magnesium and the possible involvement of the monoaminergic system in its effect in the FST. The immobility time in the FST was significantly reduced by magnesium chloride administration (30-100 mg/kg, i.p.) without accompanying changes in ambulation when assessed in an open-field test. The pre-treatment of mice with NAN-190 (0.5 mg/kg, i.p. a 5-HT(1A) receptor antagonist), WAY100635 (0.1 mg/kg, s.c., a selective 5-HT(1A) receptor antagonist), ritanserin (4 mg/kg, i.p., a 5-HT(2A/2C) receptor antagonist), ketanserin (5 mg/kg, a preferential 5-HT(2A) receptor antagonist), prazosin (1 mg/kg, i.p., an alpha(1)-adrenoceptor antagonist), yohimbine (1 mg/kg, i.p., an alpha(2)-adrenoceptor antagonist), haloperidol (0.2 mg/kg, i.p., a non selective dopaminergic receptor antagonist), SCH23390 (0.05 mg/kg, s.c., a dopamine D(1) receptor antagonist) or sulpiride (50 mg/kg, i.p., a dopamine D(2) receptor antagonist) 30 min before the administration of magnesium chloride (30 mg/kg, i.p.) significantly prevented its anti-immobility effect in the FST. Moreover, the administration of sub-effective doses of fluoxetine (10 mg/kg, i.p., serotonin reuptake inhibitor), imipramine (5 mg/kg, i.p., a mixed serotonergic noradrenergic reuptake inhibitor), bupropion (1 mg/kg, i.p., dopamine reuptake inhibitor) was able to potentiate the action of sub-effective doses of magnesium chloride. In conclusion, the present study provides evidence indicating that the antidepressant-like effect of magnesium in the FST is dependent on its interaction with the serotonergic (5-HT(1A) and 5-HT(2A/2C) receptors), noradrenergic (alpha(1)- and alpha(2)- receptors) and dopaminergic (dopamine D(1) and D(2) receptors) systems.
Update on 8 may 2015:
For the past 3 months, I was taking zinc in order to improve my testosterone and dopamine levels. I took zinc 15 mg + vitamin C 250 mg daily in mornings after food. During February 2015, I took proviton capsules + zinc 15 mg + vitamin C 250 mg combination. This produced good energy and mood. However, it produced mild non-stutterable pause also. Also, it increased blood pressure to 156/100 mmHg during the lunch time. The blood pressure dropped to normal levels during the evening hours. So, I had to change the multivitamin from proviton to Supradyn recharge. I continued the zinc but without vitamin C since supradyn recharge has enough vitamin C. This combination also produced non-stutterable pause and caused big embarrassment when I was speaking with my boss. What a pity life I live! Also, it caused poor concentration, unable to focus and less motivation to start doing things. Then, I reduced the dose of zinc to 7.5 mg by taking half tablet. Still the effects persisted with reduced intensity. I stopped zinc one day. On that day of no zinc, I felt great energy, mood and no non-stutterable pause. After that, I stopped taking zinc. That non-stutterable pause is not coming again. However, this non-stutterable pause may be caused by other minerals/vitamins also. I need to explore further and confirm.
In my research with my stuttering and interventions, I suspect the following for the non-stutterable pause. The mechanism could be lack of dopamine in the speech circuit.
1. Zinc
2. Folic acid
3. Methyl cobalamin
4. Methylfolate
5. Selenium
