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Saturday, February 19, 2011

My perceived neurocircuitary diagram

My condition is a combination of atypical depression caused by occupational social anxiety problem caused by persistent stuttering problem. So, stuttering is the root cause of my problem. Even though I overcome my stuttering during my adolescent ages, change of situations and change of language use posed greater amount of inescapable stress from the prevailing situations. This had continuously impaired my neurocircuitary resulted in worsened social anxiety with atypical depression.

Constant psychological stress caused increased corticotropin releasing hormone (CRH) from pituitary. Increased CRH caused increased cortisol levels which subsequently reduced the serotonin receptors. Also, increased CRH release might have caused increased glutamatergic and noradrenergic neurotransmission. Increased glutamatergic drive might have caused exhausted dopamine system and reduced GABA levels. Increased NA levels also might cause decreased GABA and 5-HT levels.

Also, my urine analysis report from neurogistics indicated the following.
  • Serotonin is OK.
  • Cortisol release pattern is OK except a little low release in the evening.
  • Glutamate is excessively released.
  • Dopamine is excessively released.
  • GABA is released in huge excessive.
  • Noradrenaline is released in huge excessive
  • Adrenaline is very low.

So, for me, it looks like, I have either increased CRH, increased ACTH but adrenal insufficiency. OR I may have normal CRH, normal/decreased ACTH, increased glutamate, increased dopamine and increased NE.


So, from the above diagram, it may be inferred that by reducing the CRH level all the stress axis can be normalized. As of now, there is no safe CRH antagonists available. So, the effective form of treatment could be reducing the increased glutamatergic drive and noradrenergic drive. To reduce glutamate neurotransmission, zinc, magnesium, taurine and folic acid can be used. To reduce noradrenergic neurotransmission, GABA agonists can be used.

Effect of Alprazolam SR (XANAX XR)

I took alprazolam SR (sustained release) 0.5 mg for the past 3 days. In these, three days, I did not take any multivitamin or any other drug or nutraceuticals. Also, for the past one week, I did not take any multivitamin formulations.

Positive effects:
  • Reduced anxiety
  • Able to concentrate on work and stay focused on work
  • Generally good mood
Negative effects:
  • Excessive sleepiness especially after lunch
  • Loudness of voice was low
  • Stuttering was there  - unable to complete the sentence - lack of breath control
Mechanism:
Probably increased dopaminergic neurotransmission and increased glutamate neurotransmission.