Effect of folic acid and methylcobalamin

For the past 4 months, I am not taking any supplements of modern medicine since I am taking the Siddha medicine supplements for reducing my increased LDL-C levels. These Siddha medicines produced the following effects:

Positive effects:
1. Decreased blood pressure - from 140/90 ~ 90 bpm pulse to 100/70 @ ~80 bpm pulse.
2. Stabilized mood with positive thoughts
3. Reduced stuttering while lecturing.

Negative effects:
1. Excessive tiredness
2. Lack of libido
3. Erectile dysfunction
4. Very low motivation - Unable to start any work
5. Impaired working memory and slow thinking- need extensive thinking and planning to do simple things
6. Unable to focus deeply on research papers or experiment
7. Increased LDL-C from 4.3 mg/dl to 4.6 mg/dl in 2 months time
8. Reduced capacity for exercise

Since, these negative effects have affected my progress in research, I was forced to consult a psychiatrist who prescribed escitalopram (10 mg o.d.) and folic acid (5 mg b.i.d.). I avoided taking escitalopram because I believed that any SSRI will lower my energy and ability to focus. Since I had a good experience with folic acid before, I took folic acid 5 mg, b.i.d. (one in morning and one in night). I took this folic acid along with the siddha medicines. First few days, no difference was there (probably due to deficiency of folic acid). After few days, I felt more energy and upliftment of mood and happiness. But in a week time, I developed redness and irritation in eye, severely affecting my on-screen reading. Then, I stopped taking all those siddha medicines and folic acid. Within few days, all the eye issues disappeared. After a week time, all my brain fog, tiredness and unable to focus reappeared. I thought to give a try this time with methylfolate. I took 3.25 mg of methylfolate in the morning and 3.25 mg in the night. Within few days, the eye issues reappeared forcing me to stop the folic acid.

Then, I started thinking about the methylation reactions in the body. I suspected there might be some problem with the methylation pathways in my body. Hence, I decided to give a try with methylcobalamin


Pharmacokinetics of methylcobalamin tablets VITAXON (CCL Pharmaceuticals)

Composition

Each film coated tablet contains
Mecobalamin J.P.  500 mcg

Vitaxon tablet (Mecobalamin) after single oral administration of 120-1500 mcg acquires dose-dependent peak plasma level within 3.0 hours. 40-80% of the dose is excreted in urine in first 8 hours. Repeated oral administration of 1500 mcg for 12 consecutive weeks the serum concentration increased for the first 4 weeks reaching a value twice as high as the initial concentration followed by a gradual increase reaching a peak at approximately 280% of the initial value at the 12th-week. The serum concentration declines after 12 weeks to approximately 180% of the initial 4 weeks level after the last administration.

Source:

http://www.cclpharma.com/images/productfile/0K3UP8jsdU.pdf

Histapenia - Overmethylation and its treatment

Histapenia: Histapenic depressives have a low level of histamine in blood and neuronal tissues and are believed to be individuals with high levels of the neurotransmitter dopamine. Common symptoms include high anxiety, academic underachievement, social isolation, food allergies, chemical sensitivities, low libido, dry eyes, and upper-body or head pain. About one-third experience anxiety disorders, panic attacks, or paranoia. Histapenics usually exhibit blood histamine levels below 40 mcg/dL, and react badly to anti-histamines, which naturally reduce their histamine levels even further. Treatment revolves around folic acid, vitamin B-3 (niacin or niacinamide), Vitamin B-12, and a high-protein diet. Gradual improvement usually begins within 2-4 weeks, with several months needed to properly correct this chemical imbalance.

NUTRIENTS FOR LOW DOPAMINE-Low Histamine: 
Daily in equal divided doses after full meals:Vitamin C 3000mg***, tyrosine (amino acid) (absolutely essential), 1000mg,Vitamin b6 400mg,Zinc 150mg. , gluthathione 500mg, calcium 500mg, niacin vitamin B3 3000mg,folic acid 800mcg,vitamin B12 800mcg.selenium 400mcg,Vitamin E 800 IU,manganese 5mg,NACcysteine 1000mg,and quercetin 500mg,taurine 1000mg, Vitamin E 800 IU, Magnesium 900mg,

NUTRIENTS FOR LOW ACETYLCHOLINE-High Histamines: CDPcholine 2000mg (absolutely essential),Vitamin C 3000mg***,Zinc 150mg,Vitamin B1 200mgVitam B6 300mg, acetylcarnatine 1000mg, gluthathione 500mg, calcium 500mg,taurine 3000mg, Vitamin E 800 IU, Magnesium 900mg,

NUTRIENTS FOR LOW ACETYLCHOLINE-Low Histamines: CDPcholine 2000mg (absolutely essential),Vitamin C 3000mg***,Zinc 150mg,Vitamin B1 200mgVitam B6 300mg, acetylcarnatine 1000mg, gluthathione 500mg, calcium 500mg,niacin 3000mg, vitamin B3 1500mg,folic acid 800mcg,vitamin B12 800mcg,selenium 400mcg,Vitamin E 800 IU,manganese 5mg,cysteine 500mg,and quercetin 500mg,taurine 3000mg , Vitamin E 800 IU, NACcysteine 1000mg, Magnesium 900mg,

NUTRIENTS FOR LOW GABA-High Histamines: GABA 4000mg, (absolutely essential),Vitamin C 3000mg***,Zinc 150mg, Vitamin B6 400mg,Vitamin B1 700mg,Melatonin 3mg, gluthathione 500mg, calcium 500mg,taurine 3000mg, Vitamin E 800 IU, Magnesium 900mg,

NUTRIENTS FOR LOW GABA-Low Histamines: GABA 4000mg, (absolutely essential), Niacin b3 3000mg,Vitamin C 3000mg***,Zinc 150mg, Vitamin B6 400mg,Vitamin B1 700mg,Melatonin 3mg, gluthathione 500mg,folic acid 800mcg,vitamin B12 800mcg.,selenium 400mcg,Vitamin E 800 IU,manganese 5mg, NACcysteine 1000mg,and quercetin 500mg,taurine 3000mg, Vitamin E 800 IU, Magnesium 900mg,

NUTRIENTS FOR LOW SEROTONIN-High Histamines: omega 3 fish oil EPA part 3000mg, (absolutely essential), Magnesium 900mg,Vitamin B6 400mg, Vitamin C 3000mg***,zinc 150mg, gluthathione 500mg, calcium 500mg,5htp tryptophan from griffonia bush Ghana) 3 pills, (absolutely essential),taurine 3000mg, Vitamin E 800 IU

NUTRIENTS FOR LOW SEROTONIN-Low Histamines: omega 3 fish oil EPA part 3000mg, (absolutely essential), Magnesium 900mg,Vitamin B6 400mg, Vitamin C 3000***mg,zinc 150mg, gluthathione 500mg, 5htp tryptophan from griffonia bush Ghana) 3 pills, (absolutely essential),Niacin b3 3000mg ,folic acid 800mcg,vitamin B12 800mcg.selenium 400mcg,Vitamin E 800 IU,manganese 5mg,cysteine 1000mg,and quercetin 500mg.taurine 3000mg, Vitamin E 800 IU, NACcysteine 1000mg,PLUS what other histamine you are- EITHER HIGH OR LOW HISTAMINES

Source
http://www.biochemimbal-behavior.com/

Effect of folic acid

I was taking folic acid (5 mg b.i.d) for one week. The folic acid gave me very good upliftment of mood and energy. The same effect was also observed with metyltetrahydrofolate 3.25 mg o.d. @ night. So it seems that folic acid deficiency may be present in my body. It could be genetical in origin or maybe acquired due to stress. At this time i am not taking any multivitamin tablets for the last three months. I am taking siddha medicine for hypercholesterolemia. When i am taking siddha medicine along with folic acid it gave me eye irritation and redness. So, i have to stop folic acid for a while. I need to explore further on this.